abstract：OBJECTIVES:1) To evaluate the prognostic roles of quantitative CT and pulmonary function tests and 2) to assess the association of dynamic strain and ventilation heterogeneity during unassisted spontaneous breathing with 90-day survival in patients with paraquat poisoning. DESIGN:Prospective study. SETTING:A universi...

journal_title：Critical care medicine

authors： Liu Y,Luo XJ,Li GQ,Wei LQ,Yu X,Li YM

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVES:We aimed to implement our Smart Use of Antibiotics Program to ensure the proper use of antimicrobials, improve patient care and outcomes, and reduce the risks of adverse effects and antimicrobial resistance. DESIGN:We compared the time periods before (baseline) and after (intervention) the implementation of...

journal_title：Critical care medicine

authors： Lu C,Liu Q,Yuan H,Wang L

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:We examined recommendations within critical care guidelines to describe the pairing patterns for strength of recommendation and quality of evidence. We further identified recommendations where the reported strength of recommendation was strong while the reported quality of evidence was not high/moderate and ...

journal_title：Critical care medicine

authors： Sims CR,Warner MA,Stelfox HT,Hyder JA

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVES:Monocytes and macrophages produce interleukin-1β by inflammasome activation which involves adenosine triphosphate release, pannexin-1 channels, and P2X7 receptors. However, interleukin-1β can also be produced in an inflammasome-independent fashion. Here we studied if this mechanism also involves adenosine tr...

journal_title：Critical care medicine

authors： Lee AH,Ledderose C,Li X,Slubowski CJ,Sueyoshi K,Staudenmaier L,Bao Y,Zhang J,Junger WG

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Low tidal volume (= tidal volume ≤ 6 mL/kg, predicted body weight) ventilation using volume control benefits patients with acute respiratory distress syndrome. Airway pressure release ventilation is an alternative to low tidal volume-volume control ventilation, but the release breaths generated are variable ...

journal_title：Critical care medicine

authors： Hirshberg EL,Lanspa MJ,Peterson J,Carpenter L,Wilson EL,Brown SM,Dean NC,Orme J,Grissom CK

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a role for mitochondrial DNA and N-formyl peptides in producing sys...

journal_title：Critical care medicine

authors： Lubkin DT,Bishawi M,Barbas AS,Brennan TV,Kirk AD

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVES:Case fatality in pregnancy-associated severe sepsis or septic shock appears reduced compared with nonpregnant women with severe sepsis or septic shock. It remains unclear if this difference is due to pregnancy or better baseline health status, among others. Our study compared adverse outcomes of pregnancy-as...

journal_title：Critical care medicine

authors： Kidson KM,Henderson WR,Hutcheon JA

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is increasingly used in the management of severe acute respiratory distress syndrome. With extracorporeal membrane oxygenation, select patients with acute respiratory distress syndrome can be managed without mechanical ventilation, sedation, or neuromuscular blockade. Publ...

journal_title：Critical care medicine

authors： Kurihara C,Walter JM,Singer BD,Cajigas H,Shayan S,Al-Qamari A,DeCamp MM,Wunderink R,Budinger GRS,Bharat A

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To assess the variability in short-term sepsis mortality by hospital among Centers for Medicare and Medicaid Services beneficiaries in the United States during 2013-2014. DESIGN:A retrospective cohort design. SETTING:Hospitalizations from 3,068 acute care hospitals that participated in the Centers for Medi...

journal_title：Critical care medicine

authors： Hatfield KM,Dantes RB,Baggs J,Sapiano MRP,Fiore AE,Jernigan JA,Epstein L

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To evaluate knowledge translation after publication of the target temperature management 33°C versus 36°C after out-of-hospital cardiac arrest trial and associated patient outcomes. Our primary hypothesis was that target temperature management at 36°C was rapidly adopted in Australian and New Zealand ICUs. S...

journal_title：Critical care medicine

authors： Salter R,Bailey M,Bellomo R,Eastwood G,Goodwin A,Nielsen N,Pilcher D,Nichol A,Saxena M,Shehabi Y,Young P,Australian and New Zealand Intensive Care Society Centre for Outcome and Resource Evaluation (ANZICS-CORE).

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:The electronic health record is a primary source of information for all professional groups participating in ICU rounds. We previously demonstrated that, individually, all professional groups involved in rounds have significant blind spots in recognition of patient safety issues in the electronic health reco...

journal_title：Critical care medicine

authors： Bordley J,Sakata KK,Bierman J,McGrath K,Mulanax A,Nguyen L,Mohan V,Gold JA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:Prophylactic levetiracetam is currently used in ~40% of patients with intracerebral hemorrhage, and the potential impact of levetircetam on health-related quality of life is unknown. We tested the hypothesis that prophylactic levetiracetam is independently associated with differences in cognitive function he...

journal_title：Critical care medicine

authors： Naidech AM,Beaumont J,Muldoon K,Liotta EM,Maas MB,Potts MB,Jahromi BS,Cella D,Prabhakaran S,Holl JL

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the epidemiology of hyperammonemia unrelated to liver failure in the critical care setting. DESIGN:Retrospective case series. SETTING:Critically ill patients admitted to ICUs at Mayo Clinic, Rochester, MN (medical ICU, two mixed medical-surgical ICUs, coronary care unit, or the cardiosurgical I...

journal_title：Critical care medicine

authors： Sakusic A,Sabov M,McCambridge AJ,Rabinstein AA,Singh TD,Mukesh K,Kashani KB,Cook D,Gajic O

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Our knowledge of the molecular mechanisms of sepsis has attained exponential growth. Yet, the pillars of its care remain antibiotics, fluid resuscitation, and physiologic support of failing organ systems. The inability to bring biologic breakthroughs to the bedside is not for lack of effort. Over 60 clinical ...

journal_title：Critical care medicine

authors： Lewis AJ,Lee JS,Rosengart MR

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:Thrombotic microangiopathy syndromes are a heterogeneous group of severe diseases that often require ICU admission. Prompt initiation of targeted therapies is required for atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, whereas there is no specific consensus therapy for Shiga toxi...

journal_title：Critical care medicine

authors： Joseph A,Rafat C,Zafrani L,Mariani-Kurkdjian P,Veyradier A,Hertig A,Rondeau E,Mariotte E,Azoulay E

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of perioperative intra-aortic balloon pump use in high-risk cardiac surgery patients. DESIGN:A single-center randomized controlled trial and a meta-analysis of randomized controlled trials. SETTING:Heart Institute of São Paulo University. PATIENTS:High-ri...

journal_title：Critical care medicine

authors： Rocha Ferreira GS,de Almeida JP,Landoni G,Vincent JL,Fominskiy E,Gomes Galas FRB,Gaiotto FA,Dallan LO,Franco RA,Lisboa LA,Palma Dallan LR,Fukushima JT,Rizk SI,Park CL,Strabelli TM,Gelas Lage SH,Camara L,Zeferino S,Jar

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Guidelines recommend offering family members of critically ill patients the option to attend interdisciplinary team rounds as a way to improve communication and satisfaction. Uncertainty remains around the benefits and risks. DESIGN:We conducted an observational study to describe family participation in ICU...

journal_title：Critical care medicine

authors： Au SS,Roze des Ordons AL,Parsons Leigh J,Soo A,Guienguere S,Bagshaw SM,Stelfox HT

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:We investigated whether preexisting kidney function determines if ICU patients may benefit from increased (2.0 g/kg/d) protein intake. DESIGN:Post hoc, hypothesis-generating, subgroup analysis of a multicenter, phase 2, randomized clinical trial. All analyses were conducted by intention to treat and maintai...

journal_title：Critical care medicine

authors： Zhu R,Allingstrup MJ,Perner A,Doig GS,Nephro-Protective Trial Investigators Group.

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVES:Carbon monoxide poisoning affects 50,000 per year in the United States alone. Mortality is approximately 3%, and up to 40% of survivors suffer from permanent neurocognitive and affective deficits. Hyperbaric oxygen therapy has shown benefit on reducing the long-term neurologic sequelae of carbon monoxide poi...

journal_title：Critical care medicine

authors： Rose JJ,Nouraie M,Gauthier MC,Pizon AF,Saul MI,Donahoe MP,Gladwin MT

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:To assess the feasibility, biochemical efficacy, and safety of liberal versus conventional glucose control in ICU patients with diabetes. DESIGN:Prospective, open-label, sequential period study. SETTING:A 22-bed mixed ICU of a tertiary hospital in Australia. PATIENTS:We compared 350 consecutive patients w...

journal_title：Critical care medicine

authors： Luethi N,Cioccari L,Biesenbach P,Lucchetta L,Kagaya H,Morgan R,Di Muzio F,Presello B,Gaafar D,Hay A,Crisman M,Toohey R,Russell H,Glassford NJ,Eastwood GM,Ekinci EI,Deane AM,Bellomo R,Mårtensson J

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:Because anemia of inflammation is common in ICU patients and hepcidin is the key regulator of iron homeostasis, we examined time-dependent changes in hepcidin, erythropoietin, iron, and inflammatory markers in surgical ICU patients with anemia. DESIGN:Prospective single-center clinical noninterventional stud...

journal_title：Critical care medicine

authors： Cherry-Bukowiec JR,Engoren M,Wiktor A,Raghavendran K,Napolitano LM

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Delirium occurs in approximately 30% of critically ill patients, and the risk of dying during admission doubles in those patients. Molecular mechanisms causing delirium are largely unknown. However, critical illness and the ICU environment consistently disrupt circadian rhythms, and circadian disruptions are...

journal_title：Critical care medicine

authors： Gile J,Scott B,Eckle T

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:To develop a valid, reliable measure that reflected the environment of respectfulness within the ICU setting. DESIGN:We developed a preliminary survey instrument based on conceptual domains of respect identified through prior qualitative analyses of ICU patient, family member, and clinician perspectives. Th...

journal_title：Critical care medicine

authors： Beach MC,Topazian R,Chan KS,Sugarman J,Geller G

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:In the Acute Respiratory Distress Syndrome Network randomized controlled trial, methylprednisolone treatment was associated with increased return to mechanical ventilation with partial loss of early improvements. We hypothesize a causal relationship between protocol-driven rapid discontinuation of methylpred...

journal_title：Critical care medicine

authors： Meduri GU,Bridges L,Siemieniuk RAC,Kocak M

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:Cardiac arrest etiology may be an important source of between-patient heterogeneity, but the impact of etiology on organ injury is unknown. We tested the hypothesis that asphyxial cardiac arrest results in greater neurologic injury than cardiac etiology cardiac arrest (ventricular fibrillation cardiac arrest...

journal_title：Critical care medicine

authors： Uray T,Lamade A,Elmer J,Drabek T,Stezoski JP,Missé A,Janesko-Feldman K,Garman RH,Chen N,Kochanek PM,Dezfulian C,Callaway CW,Doshi AA,Frisch A,Guyette FX,Reynolds JC,Rittenberger JC,University of Pittsburgh Post-Cardiac

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:The absence of N20 somatosensory evoked potential after cardiac arrest is related to poor outcome. However, discrimination between the low-amplitude and the absence of N20 is challenging. P25 and P30 are short-latency positive peaks with latencies between 25 and 30 ms following N20 (P25/30). P25/30 is eviden...

journal_title：Critical care medicine

authors： Kim SW,Oh JS,Park J,Jeong HH,Kim JH,Wee JH,Oh SH,Choi SP,Park KN,Cerebral Resuscitation and Outcome evaluation Within catholic Network (CROWN) Investigators.

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVES:To assess whether sepsis-associated coagulopathy predicts hospital mortality. DESIGN:Retrospective cohort study. SETTING:One-thousand three-hundred beds urban academic medical center. PATIENTS:Six-thousand one-hundred forty-eight consecutive patients hospitalized between January 1, 2010, and December 31, ...

journal_title：Critical care medicine

authors： Lyons PG,Micek ST,Hampton N,Kollef MH

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:ICU admission delays can negatively affect patient outcomes, but emergency department volume and boarding times may also affect these decisions and associated patient outcomes. We sought to investigate the effect of emergency department and ICU capacity strain on ICU admission decisions and to examine the ef...

journal_title：Critical care medicine

authors： Mathews KS,Durst MS,Vargas-Torres C,Olson AD,Mazumdar M,Richardson LD

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Radiographic criteria for acute respiratory distress syndrome have been criticized for poor reliability. Our objective was to test an educational intervention to improve the radiographic identification of acute respiratory distress syndrome by participants in the Large Observational Study to Understand the G...

journal_title：Critical care medicine

authors： Goddard SL,Rubenfeld GD,Manoharan V,Dev SP,Laffey J,Bellani G,Pham T,Fan E

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Under "Rory's Regulations," New York State Article 28 acute care hospitals were mandated to implement sepsis protocols and report patient-level data. This study sought to determine how well cases reported under state mandate align with discharge records in a statewide administrative database. DESIGN:Observa...

journal_title：Critical care medicine

authors： Prescott HC,Cope TM,Gesten FC,Ledneva TA,Friedrich ME,Iwashyna TJ,Osborn TM,Seymour CW,Levy MM

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:Hospitals use a variety of strategies to maximize the availability of limited ICU beds. Boarding, which involves assigning patients to an open bed in a different subspecialty ICU, is one such practice employed when ICU occupancy levels are high, and beds in a particular unit are unavailable. Boarding disrupt...

journal_title：Critical care medicine

authors： Stretch R,Della Penna N,Celi LA,Landon BE

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Oxygenation measured 24 hours after acute respiratory distress syndrome onset more accurately stratifies risk, relative to oxygenation at onset, in both children and adults. However, waiting 24 hours is problematic, especially for interventions that are more efficacious early in the disease course. We aimed t...

journal_title：Critical care medicine

authors： Yehya N,Thomas NJ,Khemani RG

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:To show that subjective estimate of patient's condition is related to objective cognitive and functional outcome in cardiac arrest survivors. DESIGN:Longitudinal cohort study. SETTING:ICU and Neuropsychology Service in two hospitals in Switzerland. PATIENTS:Fifty survivors included from a prospective coho...

journal_title：Critical care medicine

authors： Juan E,De Lucia M,Beaud V,Oddo M,Rusca M,Viceic D,Clarke S,Rossetti AO

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:A growing number of patients survive sepsis hospitalizations each year and are at high risk for readmission. However, little is known about temporal trends in hospital-based acute care (emergency department treat-and-release visits and hospital readmission) after sepsis. Our primary objective was to measure ...

journal_title：Critical care medicine

authors： Meyer N,Harhay MO,Small DS,Prescott HC,Bowles KH,Gaieski DF,Mikkelsen ME

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:A recent post hoc analysis suggested that driving pressure may be more important than traditional ventilatory variables in determining outcome in mechanically ventilated patients with acute respiratory distress syndrome. We conducted a systematic review and meta-analysis to summarize the risk of mortality fo...

journal_title：Critical care medicine

authors： Aoyama H,Pettenuzzo T,Aoyama K,Pinto R,Englesakis M,Fan E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians ...

journal_title：Critical care medicine

authors： Frat JP,Ragot S,Coudroy R,Constantin JM,Girault C,Prat G,Boulain T,Demoule A,Ricard JD,Razazi K,Lascarrou JB,Devaquet J,Mira JP,Argaud L,Chakarian JC,Fartoukh M,Nseir S,Mercat A,Brochard L,Robert R,Thille AW,REV

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:To determine whether contemporary β-lactam anti-infective dosing recommendations in critically ill children achieve concentrations associated with maximal anti-infective activity. The secondary objective was to describe the microbiological and clinical outcomes associated with β-lactam therapeutic drug manag...

journal_title：Critical care medicine

authors： Cies JJ,Moore WS 2nd,Enache A,Chopra A

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:To create a novel tool to predict favorable neurologic outcomes during ICU stay among children with critical illness. DESIGN:Logistic regression models using adaptive lasso methodology were used to identify independent factors associated with favorable neurologic outcomes. A mixed effects logistic regressio...

journal_title：Critical care medicine

authors： Gupta P,Rettiganti M,Gossett JM,Daufeldt J,Rice TB,Wetzel RC

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:The objectives of the present study were to evaluate, in patients with persistent arterial hypotension in the immediate postcardiac surgery period, the effects of norepinephrine infusion on ventriculo-arterial coupling, its determinants: arterial elastance and end-systolic ventricular elastance, and to test ...

journal_title：Critical care medicine

authors： Guinot PG,Longrois D,Kamel S,Lorne E,Dupont H

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVES:Chronic subdural hematoma is a commonly encountered disease in neurosurgic practice, whereas its increasing prevalence is compatible with the ageing population. Recommendations concerning postoperative thrombosis prophylaxis after burr-hole drainage of chronic subdural hematoma are lacking. The aim of this s...

journal_title：Critical care medicine

authors： Licci M,Kamenova M,Guzman R,Mariani L,Soleman J

更新日期：2018-01-01 00:00:00